2020

 

Rafiei A, Saito Y, Haralambieva E, Soldini D, Helbling PM, Chakraborty R, Merad M, Allen CE, Nombela-Arrieta C, Manz MG.  BRAFV600E or mutant MAP2K1 transduced human CD34+ cells establish Langerhans-related histiocytosis in humanized mice. Blood Advances. 

 

Pikor NB, Mörbe U, Lütge M, Gil-Cruz C, Perez-Shibayama C, Novkovic M, Cheng HW, Nombela-Arrieta C, Nagasawa T, Onder L, and Ludewig  B.  CXCL12-dependent remodeling of light and dark zone follicular dendritic cells governs the germinal center response. Nat Immunol. 2020 Jun;21(6):649-659  

 

Ghazi S, Bourgeois S, Gomariz A, Bugarski M, Haenni D, Martins JR, Nombela-Arrieta C, Wagner CA, Hall AM, Craigie E. Multiparametric imaging reveals that mitochondria rich intercalated cells in the kidney collecting duct are highly glycolytic. FASEB J. 2020 Jun;34(6):8510-8525

 

Baccin C, Al-Sabah J, Velten L, Helbling P,  Nombela-Arrieta C, Steinmetz LM, Trumpp A, and Haas S. 

Combined single-cell and spatial transcriptomics reveals fundamental principles of bone marrow niche organization.

Nat Cell Biol. 2020 Jan;22(1):38-48

 

2019

Helbling PM,  Piñeiro-Yáñez E, Gerosa R,  Boettcher S,  Al-Shahrour S, Manz MG, Nombela-Arrieta C*.  Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging and inflammation. Cell Rep 2019 Dec 3;29(10):3313-3330.e4 * corresponding author

 

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali SA, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Steurer M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O’Connor T, Weston CC, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N,  Bongers M, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin H, Alexandros Vegiopoulos, Michael Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Platelets are mediators and interventional targets of non-alcoholic steatohepatitis and liver cancer. Nature Medicine 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5 

 

Lopez-Millan B, Roca-Ho H, Diaz de la Guardia R, Gutiérrez-Agüera F, Fuster JL, Ballerini P, Nombela-Arrieta C, Bueno C, Menéndez P. NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia. Leukemia 2019 Jul;33(7):1557-1569. 

2018

Gomariz A, Helbling, Isringhausen S, Suessbier U, Becker A, Boss A, Nagasawa T, Paul G, Goksel O, Székely G, Stoma S, Nørrelykke SF, Manz MG, Nombela-Arrieta C*. Quantitative spatial analysis of hematopoiesis-regulating stromal cells in the bone marrow microenvironment by multiscale 3D microscopy. Nat Commun. 2018 Jun 28;9(1):2532. *corresponding author 

 

2017

Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C, Manz MG.  Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017 Aug 3;21(2):225-240.e5.

 

Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR. Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol 2017 Apr 1;198(7):2854-2864

2016

Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Shin-Young Park, Fabien Loison, Jiro Sakai, Yuanfu Xu, Leslie E. Silberstein, and Hongbo R. Luo. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med 2016 Sep 19;213(10):1999-2018  

 

2015

Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR.  Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20;42(1):159-71. 

2014

Gazit R, Mandal P, Ebina W, Ben-Zvi A, Nombela-Arrieta C, Silberstein LE, Rossi DJ. Fgd5 identifies hematopoietic stem cells in the murine bone marrow and is not required for definitive Hematopoiesis. J Exp Med 2014 Jun 30;211(7):1315-31 

 

2013

Nombela-Arrieta C*, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE* 

Quantitative Imaging of Hematopoietic Stem and Progenitor Cell localization and hypoxic status in the Bone Marrow microenvironment. Nat Cell Biol, 2013 May 15(5):533-43. * co-corresponding author 

 

Casanova-Acebes M, Pitaval C*, Weiss LA*, Nombela-Arrieta C*, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A.  Rhythmic modulation of the hematopoietic stem cell niche through neutrophil clearance.  Cell, 2013 May 153(5):1025-35. *equal contribution 

 

Liang OD, Lu J, Nombela-Arrieta C, Pivarnik G, Chai LE, Silberstein LE, and Luo HR. Deficiency of Lipid Phosphatase SHIP Enables Reconstitution of Bone Marrow Microenvironment. Dev Cell, 2013 May 25(4):333-49

 

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 Levels Balance Cell Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells. Mol Cell, 2013 Mar 49(5):934-46.

 

Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE. 

FAK regulates progenitor B-cell growth and retention in their bone marrow microenvironments. J Immunol, 2013 Feb 190(3):1094-102. 

 

Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In Vivo Generation of Transplantable Human Hematopoietic Cells from Induced Pluripotent Stem Cells. Blood 2013 Feb 121(8):1255-64. 

      

2012

Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak Depletion in Both Hematopoietic and Non-hematopoietic Niche cells Leads to Hematopoietic Stem Cell Expansion. Exp Hematol, 2012 Apr 40(4):307-317. 

 

2007

Nombela-Arrieta C*, Mempel TR*, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH, Stein JV. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med, 2007 Mar 204(3):497-510. 

 

2006

García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Fukui Y, Stein JV, Teixidó. DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β1.  J Immunol, 2006 Oct 177(8):5215-25

2005

Garcia-Bernal D, Wright N, Sotillo-Mallo E, Nombela-Arrieta C, Stein JV, Bustelo XR, Teixido J. Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta.  Mol Biol Cell, 2005 Jul16(7):3223-35 

 

2004

Nombela-Arrieta C, Lacalle RA, Montoya MC, Megías D, Marqués M, Carrera AC, Mañes S, Fukui Y, Martinez-A C, Stein JV.  Differential requirements for DOCK2 and phosphoinositide-3-kinaseγ during T and B lymphocyte homing. Immunity, 2004 Sep 21(3):429-41. 

 

2003

Stein JV, Fernández-Soriano S, M’Rini C, Nombela-Arrieta C, González de Buitrago G, Rodríguez-Frade JM, Mellado M, Girard JP, Martinez-A C. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Blood , 2003 Jan101(1):38-4