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Publications

2024

Kuo YP, Nombela-Arrieta C, Carja O. A theory of evolutionary dynamics on any complex population structure reveals stem cell niche architecture as a spatial suppressor of selectionNat Commun. 2024 May 31;15(1):4666. doi: 10.1038/s41467-024-48617-2.

 

López-Gil JC, García-Silva S, Ruiz-Cañas L, Navarro D, Palencia-Campos A, Giráldez-Trujillo A, Earl J, Dorado J, Gómez-López G, Monfort-Vengut A, Alcalá S, Gaida MM, García-Mulero S, Cabezas-Sáinz P, Batres-Ramos S, Barreto E, Sánchez-Tomero P, Vallespinós M, Ambler L, Lin ML, Aicher A, García García de Paredes A, de la Pinta C, Sanjuanbenito A, Ruz-Caracuel I, Rodríguez-Garrote M, Guerra C, Carrato A, de Cárcer G, Sánchez L, Nombela-Arrieta C, Espinet E, Sanchez-Arevalo Lobo VJ, Heeschen C, Sainz B Jr. The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells. Gut. 2024 May 16:gutjnl-2023-330995.

 

Schyrr F, Alonso Calleja A, Vijaykumar A, Sordet-Dessimoz J, Gebhard S, Sarkis R, Bataclan C, Ferreira Lopes S, Oggier ALJ, de Leval LL, Nombela-Arrieta C, Naveiras OM. Inducible CXCL12/CXCR4-dependent extramedullary hematopoietic niches in the adrenal gland. Blood 2024 May 10: blood.2023020875

2023

Marques-Maggio E, Maccio U, Marx A, Galli S, Schwab N, Frank A, Hamelin B, Varga Z, Nombela-Arrieta C, Mertz KD, Theocharides AP, Koelzer VH. Bone marrow haematopoiesis in patients with COVID-19. Histopatholgy. 2023 Oct;83(4):582-590

 

Ni R, Straumann N, Fazio S, Dean-Ben XL, Louloudis G, Keller C, Razansky D, Ametamey S, Mu L, Nombela-Arrieta C, Klohs J.

Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusionPhotoacoustics 2023 Jul 15;32:100532.

 

Shao L, Paik NY, Sanborn MA, Bandara T, Vijaykumar A, Sottoriva K, Rehman J, Nombela-Arrieta C, Pajcini KV. Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cellsProc Natl Acad Sci U S A. 2023 May 16;120(20):e2210058120

 

Yamada Y, Nguyen TT, Impellizzieri D, Mineura K, Shibuya R, Gomariz A, Haberecker M, Nilsson J, Nombela-Arrieta C, Jungraithmayr W, Boyman O. Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in miceNat Commun. 2023 Mar 13;14(1):1383

 

Barz MJ, Behrmann L, Capron D, Zuchtriegel G, Steffen FD, Kunz L, Zhang Y, Vermeerbergen IJ, Marovca B, Kirschmann M, Zech A, Nombela-Arrieta C, Ziegler U, Schroeder T, Bornhauser B, Bourquin JP. B and T cell acute lymphoblastic leukemia evade chemotherapy at distinct sites in the bone marrow. Haematologica  2023 May 1;108(5):1244-1258 

 

2022

​Bührer ED, Amrein MA, Forster S, Isringhausen S, Schürch CM, Bhate SS, Brodie T, Zindel J, Stroka D, Sayed MA, Nombela-Arrieta C, Radpour R, Riether C, Ochsenbein AF. Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance. Leukemia 2022 Nov;36(11):2634-2646. 

 

Sparano C, Solís-Sayago D, Vijaykumar A, Rickenbach C, Vermeer M, Ingelfinger F, Litscher G, Fonseca A, Mussak C, Mayoux M, Friedrich C, Nombela-Arrieta C, Gasteiger G, Becher B, Tugues S. Embryonic and neonatal waves generate distinct populations of hepatic ILC1sSci Immunol. 2022 Sep 2;7(75):eabo6641. 

 

Li W, Liu YH, Estrada H, Rebling J, Reiss M, Galli S, Nombela-Arrieta C, Razansky D

Tracking Strain-Specific Morphogenesis and Angiogenesis of Murine Calvaria with Large-Scale Optoacoustic and Ultrasound MicroscopyJ. Bone Miner Res. 2022 May;37(5):1032-1043.

 

Gomariz A, Portenier T, Nombela-Arrieta C, Goksel O. Probabilistic spatial analysis in quantitative microscopy with uncertainty-aware cell detection using deep Bayesian regressionScience Advances. 2022 Feb 4;8(5):

 

Kovtonyuk L.V, Caiado F, Garcia-Martin S, Manz E-M, Helbling PM, Takizawa H, Boettcher S, Al-Shahrour F, Nombela Arrieta C, Slack E, and Manz MG. 2021. IL-1 Mediates Microbiome-Induced Inflamm-Ageing of Hematopoietic Stem Cells in Mice.

2022 Jan 6;139(1):44-58

2021

Isringhausen S , Suessbier U, Kovtonyuk L , Kraeutler N, Helbling PM, Gomariz-Carillo A, Wong, HC, Nagasawa T, Manz M, Oxenius A, Nombela-Arrieta C* . CD8 T cells induce destruction of bone marrow stromal niches and hematopoietic stem cell dysfunction in chronic viral infections. J Exp Med. 2021, 218(12):e20192070

Gomariz A, Portenier T, Helbling PM, Isringhausen S, Suessbier U, Nombela-Arrieta, C*, Goksel O*. 

Modality attention and sampling enables deep learning with heterogeneous marker combinations in fluorescence microscopy. *co-last and senior author. Nat Mach Intell. 2021 Sep;3(9):799-811

 

Mun YV, and Nombela-Arrieta C*. 3D Microscopy of Murine Bone Marrow Hematopoietic Tissues. Bone Marrow Microenvironment: Methods and Protocols. Methods Mol Biol. 2021;2308:127-138. Springer publications *corresponding author

Zavala F , Nombela-Arrieta C, Ben Nasr M, Fiorina P. The Role of Hematopoietic Progenitors in Immune Regulation and Memory. 2021 Nov 12;12:789139

 

Gerosa R, Boettcher S,  Kovtonyuk LV, Hausmann A, Hardt W-D, Hidalgo J, Nombela Arrieta C, and Manz MG. 2021. 

CXCL12-abundant Reticular Cells are the Major Source of IL-6 Upon LPS-stimulation and Thereby Regulate Hematopoiesis. Blood Adv. 2021 Dec 14;5(23):5002-5015

 

Diaz de la Guardia, R, Velasco-Hernandez T, Gutiérrez-Agüera F, Roca-Ho H, Molina O, Nombela Arrieta C, Bataller A, Fuster JL, Anguita E, Vives S, Zamora L, Nomdedeu JF, Gomez-Casares MT, Ramírez-Orellana M, Lapillonne H, Ramos-Mejia V, Rodríguez-Manzaneque JC, Bueno C, Lopez-Millan B, and Menéndez P.  Engraftment characterization of risk-stratified AML patients in NSGS mice. Blood Adv. 2021;5(23):4842-4854

 

Pagella P, Nombela-Arrieta C, Mitsiadis TA. Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth. Int J Mol Sci. 2021 Mar 16;22(6):3024.

2020

 

Gomariz A, Isringhausen S, Helbling P, Nombela-Arrieta C*.  Spatial analysis of hematopoietic stem cell niches.

Annals of the New York Academy of Sciences 2020 Apr;1466(1):5-16 *corresponding author 

Rafiei A, Saito Y, Haralambieva E, Soldini D, Helbling PM, Chakraborty R, Merad M, Allen CE, Nombela-Arrieta C, Manz MG. BRAFV600E or mutant MAP2K1 transduced human CD34+ cells establish Langerhans-related histiocytosis in humanized mice. Blood Advances. 

 

Pikor NB, Mörbe U, Lütge M, Gil-Cruz C, Perez-Shibayama C, Novkovic M, Cheng HW, Nombela-Arrieta C, Nagasawa T, Onder L, and Ludewig  B.  CXCL12-dependent remodeling of light and dark zone follicular dendritic cells governs the germinal center response. Nat Immunol. 2020 Jun;21(6):649-659  

 

Ghazi S, Bourgeois S, Gomariz A, Bugarski M, Haenni D, Martins JR, Nombela-Arrieta C, Wagner CA, Hall AM, Craigie E. Multiparametric imaging reveals that mitochondria rich intercalated cells in the kidney collecting duct are highly glycolyticFASEB J. 2020 Jun;34(6):8510-8525

 

Baccin C, Al-Sabah J, Velten L, Helbling P,  Nombela-Arrieta C, Steinmetz LM, Trumpp A, and Haas S. 

Combined single-cell and spatial transcriptomics reveals fundamental principles of bone marrow niche organization.

Nat Cell Biol. 2020 Jan;22(1):38-48

 

2019

Helbling PM,  Piñeiro-Yáñez E, Gerosa R,  Boettcher S,  Al-Shahrour S, Manz MG, Nombela-Arrieta C*.  Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging and inflammation. Cell Rep 2019 Dec 3;29(10):3313-3330.e4 * corresponding author

Suessbier U, and Nombela-Arrieta C*.  Assessing cellular hypoxic status in situ within the bone marow microenvironment

Stem Cell Mobilization Methods Mol Biol. 2019;2017:123-134. Springer publications *corresponding author

 

Agarwal P, Isringhausen S, Li H, Paterson AJ, He J, Gomariz A, Nagasawa T, Nombela-Arrieta C, Bhatia R. 

CXCL12-expressing mesenchymal progenitor niches maintain quiescent, treatment-resistant leukemia stem cells

Cell Stem Cell 2019 May 2;24(5):769-784.e6

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali SA, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Steurer M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O’Connor T, Weston CC, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N,  Bongers M, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin H, Alexandros Vegiopoulos, Michael Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M. Platelets are mediators and interventional targets of non-alcoholic steatohepatitis and liver cancer. Nature Medicine 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5 

 

Lopez-Millan B, Roca-Ho H, Diaz de la Guardia R, Gutiérrez-Agüera F, Fuster JL, Ballerini P, Nombela-Arrieta C, Bueno C, Menéndez P. NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia. Leukemia 2019 Jul;33(7):1557-1569. 

2018

Gomariz A, Helbling, Isringhausen S, Suessbier U, Becker A, Boss A, Nagasawa T, Paul G, Goksel O, Székely G, Stoma S, Nørrelykke SF, Manz MG, Nombela-Arrieta C*. Quantitative spatial analysis of hematopoiesis-regulating stromal cells in the bone marrow microenvironment by multiscale 3D microscopy. Nat Commun. 2018 Jun 28;9(1):2532. *corresponding author 

 

2017

Nombela-Arrieta C*, Manz MG. Quantification and three-dimensional microanatomical organization of the bone marrow. Blood Advances 2017 Feb 1 (6), 407-416 *corresponding author 

 

Nombela-Arrieta C*, Isringhausen S. The Role of the Bone Marrow Stromal Compartment in the Hematopoietic Response to Microbial InfectionsFront Immunol. 2017 Jan 20;7:689 *corresponding author 

Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C, Manz MG.  Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017 Aug 3;21(2):225-240.e5.

 

Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR. Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol 2017 Apr 1;198(7):2854-2864

2016

Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Shin-Young Park, Fabien Loison, Jiro Sakai, Yuanfu Xu, Leslie E. Silberstein, and Hongbo R. Luo. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med 2016 Sep 19;213(10):1999-2018  

 

2015

Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR.  Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20;42(1):159-71. 

2014

Gazit R, Mandal P, Ebina W, Ben-Zvi A, Nombela-Arrieta C, Silberstein LE, Rossi DJ. Fgd5 identifies hematopoietic stem cells in the murine bone marrow and is not required for definitive Hematopoiesis. J Exp Med 2014 Jun 30;211(7):1315-31 

Nombela-Arrieta C, Silberstein LE.  The Science behind the hypoxic niche of hematopoietic stem and progenitor cells.

Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):542-7.

 

2013

Nombela-Arrieta C*, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE* 

Quantitative Imaging of Hematopoietic Stem and Progenitor Cell localization and hypoxic status in the Bone Marrow microenvironment. Nat Cell Biol, 2013 May 15(5):533-43. * co-corresponding author 

 

Casanova-Acebes M, Pitaval C*, Weiss LA*, Nombela-Arrieta C*, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A.  Rhythmic modulation of the hematopoietic stem cell niche through neutrophil clearance.  Cell, 2013 May 153(5):1025-35. *equal contribution 

 

Liang OD, Lu J, Nombela-Arrieta C, Pivarnik G, Chai LE, Silberstein LE, and Luo HR. Deficiency of Lipid Phosphatase SHIP Enables Reconstitution of Bone Marrow Microenvironment. Dev Cell, 2013 May 25(4):333-49

 

Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 Levels Balance Cell Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells. Mol Cell, 2013 Mar 49(5):934-46.

 

Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE. 

FAK regulates progenitor B-cell growth and retention in their bone marrow microenvironments. J Immunol, 2013 Feb 190(3):1094-102. 

 

Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In Vivo Generation of Transplantable Human Hematopoietic Cells from Induced Pluripotent Stem Cells. Blood 2013 Feb 121(8):1255-64. 

      

2012

Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak Depletion in Both Hematopoietic and Non-hematopoietic Niche cells Leads to Hematopoietic Stem Cell Expansion. Exp Hematol, 2012 Apr 40(4):307-317. 

2011

Nombela-Arrieta C, Ritz J, Silberstein LE. The elusive nature of Mesenchymal Stem Cells. Nat Rev Mol Cell Biol, 2011 Feb 12(2):126-31. 

 

2007

Nombela-Arrieta C*, Mempel TR*, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH, Stein JV. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med, 2007 Mar 204(3):497-510. 

 

2006

García-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Fukui Y, Stein JV, Teixidó. DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β1.  J Immunol, 2006 Oct 177(8):5215-25

2005

Stein JV, Nombela-Arrieta C.  Chemokine control of lymphocyte trafficking: a general overview. Immunology , 2005 Sep 116(1):1-12 

Garcia-Bernal D, Wright N, Sotillo-Mallo E, Nombela-Arrieta C, Stein JV, Bustelo XR, Teixido J. Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta.  Mol Biol Cell, 2005 Jul16(7):3223-35 

 

2004

Nombela-Arrieta C, Lacalle RA, Montoya MC, Megías D, Marqués M, Carrera AC, Mañes S, Fukui Y, Martinez-A C, Stein JV.  Differential requirements for DOCK2 and phosphoinositide-3-kinaseγ during T and B lymphocyte homing. Immunity, 2004 Sep 21(3):429-41. 

 

2003

Stein JV, Fernández-Soriano S, M’Rini C, Nombela-Arrieta C, González de Buitrago G, Rodríguez-Frade JM, Mellado M, Girard JP, Martinez-A C. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Blood , 2003 Jan101(1):38-4 

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